Photobiomodulation for Pain

“PBM (photobiomodulation) refers to the use of light in the red or near-infrared region, with wavelengths usually in the range of 600 to 700nm and 780 to 1100 nm, and the laser or LEDs typically having an irradiance or power density between 5 mW cm−2 to 5 W cm−2. … Moreover red/NIR light is chosen because its penetration through tissue is maximal in this wavelength range, due to lower scattering and absorption by tissue chromophores. … The studies performed for PBM on acute pain and pre-operative analgesia show that a single treatment (usually only 30–60 seconds) is enough to cause analgesia, while for chronic pain and some degenerative conditions, more sessions are required. … Clinical studies have demonstrated the efficacy of laser-induced analgesia, usually with a low power red or near-infrared laser, and it seems that the pain reduction is due to a conduction block of central and peripheral nerve fibers and to the release of endorphins.”


Photobiomodulation for Immunity

“Macrophages are important antigen-presenting cells, and are involved in the induction of primary immunologic response…. Recently, Chen reported that 660 nm PBM could promote M1 polarization of monocytes, and influence the expression of cytokines and chemokines at the level of mRNA and protein expression…. M1-related immunoregulation is important for antiviral immunity, antitumor immunity, and for the pathogenesis of infammation in autoimmune conditions, therefore PBM could help promoting anti-viral and anti-tumor immunity”


Photobiomodulation for Inflammation

“PBM is able to up-regulate anti-oxidant defenses and reduce oxidative stress. It was shown that PBM can activate NF-kB in normal quiescent cells, however in activated inflammatory cells, inflammatory markers were decreased. One of the most reproducible effects of PBM is an overall reduction in inflammation, which is particularly important for disorders of the joints, traumatic injuries, lung disorders, and in the brain…. PBM can reduce inflammation in the brain, abdominal fat, wounds, lungs, spinal cord.”

AIMS Biophys • 2017

Photobiomodulation for Healing

“HSP70 (Heat Shock Protein 70) is part of the normal wound healing process, alongside IL-6 and TGF-β1. Visible (532 nm) and NIR (815 nm) light have been demonstrated to induce HSP70 expression in treated skin cells, and this is important for skin rejuvenation interventions, since there is a consequent effect consisting on the assistance of the correct folding and transport of newly synthesized collagen.”


Photobiomodulation for Performance

“Both pre-conditioning (light delivered to muscles before exercise) and PBM applied after exercise can increase sports performance in athletes…. PBM can increase muscle mass gained after training, and decrease inflammation and oxidative stress in muscle biopsies.”


Photobiomodulation for Anxiety

“Of the 15 recruited subjects (mean age 30 ± 14 years; 67% women), 12 (80%) completed the open trial. Results show a significant reduction in the total scores of [the Hamilton Anxiety Scale]… as well as significant improvements in sleep. T-PBM (transcranial photobiomodulation) was well tolerated with no serious adverse events. Based on our pilot study, t-PBM with NIR (near infra-red light) is a promising alternative treatment for GAD (negeralized anxiety disorder).